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TRPV1のギャングリオン特異のスプライシングは,吸血鬼蝙蝠の赤外線感覚の基礎となっている
Elena O Gracheva1, Julio F Cordero-Morales, José A González-Carcacía
1Department of Physiology, University of California, San Francisco, California 94158-2517, USA.
Nature
|August 5, 2011
まとめ
吸血鬼コウモリは,改変されたTRPV1チャンネルを使用して赤外線を検出し,熱感を低下させます. トライジェミナル神経におけるこのユニークな分子適応は,暖かい血の獲物を見つけることを可能にします.
科学分野:
- 分子生物学は分子生物学である.
- 神経科学は神経科学である.
- 進化生物学の進化生物学について
背景:
- 吸血鬼コウモリには,獲物を検出するために赤外線を検出するユニークな能力があります.
- この赤外線感知は,トライジェミナル神経繊維によって神経化される特殊なピット臓器によって媒介されます.
- 蝙蝠と特定のヘビの両方とも極端な熱感性を進化させ,熱受容体の進化の洞察を提供している.
研究 の 目的:
- 吸血鬼コウモリにおける赤外線検出の基礎となる分子機構を調査するために.
- 吸血鬼のコウモリが,獲物を特定するために熱感を調節する方法を理解するために.
- コウモリにおけるTRPV1チャネル適応の進化的基礎を探求する.
主な方法:
- 吸血鬼コウモリコウモリコウモリコウモリコウモリコウモリコウモリコウモリコウモリコウモリコウモリコウモリコウモリコウモリコウモリコウモリコウモリコウモリコウモリコウモリコウモリコウモリコウモリコウモリコウモリコウモリコウモリコウモリ
- 蝙蝠と他のLaurasiatheria哺乳類のTRPV1遺伝子組織の比較.
- TRPV1チャンネル変数の機能的特徴.
主要な成果:
- 吸血鬼コウモリは,既に熱に敏感なチャンネルであるTRPV1を利用して赤外線を検出します.
- トライジェミナルガングリアにおけるTRPV1トランスクリプトの代替スプライシングにより,その活性化値が約30°Cに低下します.
- このスプライシングはトライジェミナル・ギャングリアに特異的に発生し,他の場所で有害な熱を検出するTRPV1の役割を保持します.
- バットTrpv1遺伝子の組織はLaurasiatheria哺乳類に保存されており,共通の進化史を示唆しています.
結論:
- ヴァンパイアコウモリコウモリコウモリコウモリコウモリコウモリコウモリコウモリコウモリコウモリコウモリコウモリコウモリコウモリコウモリコウモリコウモリコウモリコウモリコウモリコウモリコウモリコウモリコウモリコウモリコウモリコウモリコウモリコウモリコウモリ
- この分子機構は,熱感神経繊維の調節のための新しい戦略を表しています.
- この発見は,熱受容体の進化的可塑性を強調し,コウモリ特有の適応に関する洞察を提供します.
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