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Updated: May 30, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
09:08

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028

Published on: January 13, 2017

アスペルギルス・ニドゥランス (Aspergillus nidulans) のポリケチド合成酵素ドメインを交換することで"非自然"な自然製品を作り出す

Ting Liu1, Yi-Ming Chiang, Amber D Somoza

  • 1Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California 90089, United States.

Journal of the American Chemical Society
|August 6, 2011
PubMed
まとめ

研究者はドメインを交換することでハイブリッドポリケチド合成酵素 (PKS) を設計した. このPKSは新しい代謝物を生成し,特定のドメインによってPKS製品鎖の長さを正確に制御することを示唆しています.

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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products07:59

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

Published on: October 4, 2019

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