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Updated: May 30, 2026

Preparation of Meiotic Chromosome Spreads from Mouse Oocytes for Assessment of Synapsis and Recombination
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Preparation of Meiotic Chromosome Spreads from Mouse Oocytes for Assessment of Synapsis and Recombination

Published on: July 18, 2025

自己誘発的なメオティック不安定性から重複的なDNA境界の保護

Gerben Vader1, Hannah G Blitzblau, Mihoko A Tame

  • 1Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA.

Nature
|August 9, 2011
PubMed
まとめ

繰り返されるDNA配列におけるDNA二重鎖断裂 (DSB) は,微分化の過程でリスクをもたらす. イーストの研究は,rDNA配列の境界がDSBに敏感であることを明らかにし,ゲノム不安定性と疾患に関連する再編成を防ぐために特定の保護を必要とする.

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