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Updated: May 30, 2026

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers
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エステル結合形成非リボソームペプチド合成酵素モジュールによるクリプトフィシン抗がん剤の化学酵素合成

Yousong Ding1, Christopher M Rath, Kyle L Bolduc

  • 1Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA.

Journal of the American Chemical Society
|August 10, 2011
PubMed
まとめ

研究者は,Crpp (クリプトフィシン) アナログを合成するために,CrpD-M2酵素を用いた新しい化学酵素法を開発しました. このアプローチでは,2-ヒドロキシ酸分子が成功裏に組み込まれ,新しい抗癌薬の開発への道が開けました.

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