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関連する概念動画

A Versatile, Behavioral Method to Investigate Thyroid Hormone Effects on Cerebellar Function04:05

A Versatile, Behavioral Method to Investigate Thyroid Hormone Effects on Cerebellar Function

748
Here we present a protocol for a versatile behavior test developed recently, the ladder beam test. This test has the advantage of detecting subtle cerebellar ataxia caused by a defect of thyroid hormone action in the central nervous system over the conventional behavior tests assessing motor performance.
748
In vivo Characterization of Endocrine Disrupting Chemical Effects via Thyroid Hormone Action Indicator Mouse04:14

In vivo Characterization of Endocrine Disrupting Chemical Effects via Thyroid Hormone Action Indicator Mouse

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The Thyroid Hormone Action Indicator mouse model was developed to enable tissue-specific quantification of local thyroid hormone action using its endogenous regulatory machinery. Recently, it has been shown that the model is suitable for characterizing endocrine-disrupting chemicals interacting with thyroid hormone economy, both by ex vivo and in vivo...
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An Ex vivo Model to Study Hormone Action in the Human Breast12:31

An Ex vivo Model to Study Hormone Action in the Human Breast

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We have developed a novel ex vivo model to study hormone action in the human breast. It is based on tissue microstructures isolated from surgical breast tissue specimens which preserve tissue architecture, intercellular interactions, and paracrine...
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Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

5.0K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
5.0K
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

7.2K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
7.2K
Secondary Messengers in Hormone Action01:26

Secondary Messengers in Hormone Action

4.7K
Water-soluble hormones cannot cross the plasma membrane, so they rely on protein receptors that span the membrane to trigger intracellular signaling pathways. These pathways then activate second messengers inside the cell, including cAMP or calcium ions.
Many hormones bind to transmembrane G protein-coupled receptors that connect to regulatory G proteins. These G proteins can then activate enzymes such as adenylyl cyclase or phospholipase C. Adenylyl cyclase converts ATP to cAMP, activating...
4.7K

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関連する実験動画

Updated: Jan 20, 2026

Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse
04:05

Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse

Published on: October 6, 2023

748

細胞レベルで甲状腺ホルモンの作用

J H Oppenheimer

    Science (New York, N.Y.)
    |March 9, 1979
    PubMed
    まとめ
    この要約は機械生成です。

    甲状腺ホルモンの作用は,メッセンジャーRNA (mRNA) の合成を調節する核受容体複合体を含む. 受容体数ではなく,この複合体に対する細胞の感受性は,甲状腺ホルモン反応の鍵であるようです.

    さらに関連する動画

    Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
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    Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

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    An Ex vivo Model to Study Hormone Action in the Human Breast
    12:31

    An Ex vivo Model to Study Hormone Action in the Human Breast

    Published on: January 8, 2015

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    関連する実験動画

    Last Updated: Jan 20, 2026

    Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse
    04:05

    Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse

    Published on: October 6, 2023

    748
    Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
    04:14

    Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

    Published on: October 6, 2023

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    An Ex vivo Model to Study Hormone Action in the Human Breast
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    An Ex vivo Model to Study Hormone Action in the Human Breast

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    科学分野:

    • 分子内分泌学分子内分泌学
    • 遺伝子規制 遺伝子規制
    • 細胞生物学 細胞生物学

    背景:

    • 甲状腺ホルモンの細胞効果は,核受容体複合体によって媒介されます.
    • この複合体は,様々なメッセンジャーRNA (mRNA) 配列の生成に影響を与えます.

    研究 の 目的:

    • 細胞レベルで甲状腺ホルモンの作用の調節メカニズムを探求する.
    • 遺伝子発現におけるトリヨドチロニン核受容体複合体の役割を調査する.

    主な方法:

    • 甲状腺ホルモンに対する反応としてmRNA配列の変化の分析.
    • トライヨドチロニン核受容体複合体に対する細胞の感受性の検査.

    主要な成果:

    • 証拠によると,トリヨドチロニン核受容体複合体は,甲状腺ホルモンの作用の基本単位である.
    • mRNA濃度の一般的および特異的な上昇の両方が観察されました.
    • 細胞の調節は局所的に発生し,感受性はポスト受容体レベルで潜在的に調節されます.

    結論:

    • 甲状腺ホルモンの作用は,細胞内で局所的に調節され,おそらく受容体後部位にあります.
    • トライヨドチロニン核受容体複合体に対する感受性の選択的変化は,特定の標的遺伝子で発生する.
    • 受容体位数は,甲状腺ホルモン反応の信頼できる指標ではありません.