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関連する概念動画

Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...

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関連する実験動画

Updated: May 30, 2026

Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries
10:58

Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries

Published on: September 6, 2012

複数の成分をプログラム的に放出するための複数のポリマーソーム.

Shin-Hyun Kim1, Ho Cheung Shum, Jin Woong Kim

  • 1School of Engineering and Applied Sciences and Department of Physics, Harvard University, Cambridge, Massachusetts, United States.

Journal of the American Chemical Society
|August 16, 2011
PubMed
まとめ
この要約は機械生成です。

研究者は,複数の成分を制御的に放出するためのポリマーソーム-イン-ポリマーソームを作成するためのマイクロフリウイド法を開発しました. この新しい配送システムは,医薬品および化粧品のアプリケーションのための高エンカプスレーション効率とプログラム性を提供します.

さらに関連する動画

Forming Giant-sized Polymersomes Using Gel-assisted Rehydration
08:45

Forming Giant-sized Polymersomes Using Gel-assisted Rehydration

Published on: May 26, 2016

Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation
06:57

Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation

Published on: August 11, 2018

関連する実験動画

Last Updated: May 30, 2026

Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries
10:58

Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries

Published on: September 6, 2012

Forming Giant-sized Polymersomes Using Gel-assisted Rehydration
08:45

Forming Giant-sized Polymersomes Using Gel-assisted Rehydration

Published on: May 26, 2016

Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation
06:57

Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation

Published on: August 11, 2018

科学分野:

  • バイオマテリアル科学 バイオマテリアル科学
  • ナノテクノロジー ナノテクノロジー
  • 化学工学は化学工学というものです.

背景:

  • ポリマーソームは有望な薬物投与手段ですが,共封入と複数の成分の制御された放出で苦労しています.
  • 現在の方法は,単一の配送システム内で複数のペイロードを独立して管理する能力が欠如しており,医薬品や化粧品でのアプリケーションを制限しています.

研究 の 目的:

  • 多重構成要素をカプセル化して順番に放出できる多層ポリマーソームを作成するためのマイクロ流体アプローチを開発する.
  • 多様な物質の制御された長期貯蔵と放出を,交叉汚染なしに可能にする.

主な方法:

  • 多層ポリマーソームのテンプレートとして機能する単分散二重乳液滴を生成するために,マイクロ流体技術が採用されました.
  • エムルションフェーズを順次注入することで",ポリマーソーム-イン-ポリマーソーム"構造が形成された.
  • 水嫌性ホモポリマーを二重層に組み込むことは,プログラムされた,連続的な膜解離を容易にしました.

主要な成果:

  • 高濃縮効率で多層の"ポリマーソーム・イン・ポリマーソーム"を成功裏に生産しました.
  • 制御された二重層解離を通じて,封装されたコンポーネントのプログラムされ,連続的に放出されることが実証されています.
  • 微流体法では,より高次元の複雑なポリマーソーム構造を作成することができます.

結論:

  • 開発されたマイクロ流体アプローチにより,多成分配送のための高度なポリマーソームシステムの作成が可能になります.
  • この技術は,プログラム可能で連続的な放出能力を提供し,既存のポリマーソーム車両の限界を克服します.
  • この方法の生物互換性と効率性は,さまざまな産業における洗練された配送システムに新しい道を開く.