関連する実験動画

Updated: May 30, 2026

Utilizing Time-Resolved Protein-Induced Fluorescence Enhancement to Identify Stable Local Conformations One α-Synuclein Monomer at a Time
07:56

Utilizing Time-Resolved Protein-Induced Fluorescence Enhancement to Identify Stable Local Conformations One α-Synuclein Monomer at a Time

Published on: May 30, 2021

α-シヌクレインは,統合に抵抗する螺旋的に折りたたまれたテトラメアとして生理学的に発生します

Tim Bartels1, Joanna G Choi, Dennis J Selkoe

  • 1Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

Nature
|August 16, 2011
PubMed
まとめ

パーキンソン病は,アルファ-シヌクレイン (α-シヌクレイン) が誤った折り畳みを伴う. この研究は,内生性α-シヌクレインがモノマーではなく安定したテトラメアを形成することを明らかにし,テトラメア安定化がパーキンソン病の病理学を予防する可能性があることを示唆しています.

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