男性と女性の喫煙と膀がんのリスクとの関連性
Neal D Freedman1, Debra T Silverman, Albert R Hollenbeck
1Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Blvd, EPS/320, MSC 7232, Rockville, MD 20852, USA. freedmanne@mail.nih.gov
JAMA
|August 18, 2011
まとめ
喫煙は膀がんのリスクを大幅に高め,現在の喫煙者は,決して喫煙していない人の4倍以上のリスクに直面しています. 喫煙による膀がんの集団関連リスクは,男性と女性の両方でかなり高い.
科学分野:
- エピデミオロジー エピデミオロジー
- 腫瘍学 腫瘍学
- 公衆衛生は公衆衛生である.
背景:
- タバコの喫煙は膀がんの主な危険因子であり,以前の推定では,男性では50~65%,女性では20~30%の割合で人口の帰属リスク (PAR) を示唆していた.
- 現在の喫煙者は,決して喫煙していない人と比較して,膀がんのリスクが3倍になる.
- 30年以上にわたって米国で安定した罹患率は,喫煙パターンとタバコの組成の変化により,喫煙に関連するリスクの再評価を必要とします.
研究 の 目的:
- タバコの喫煙と膀がんの関連性を評価する.
- 現代的なコホートにおける喫煙と膀がんのリスク推定を更新する.
主な方法:
- 281,394人の男性と186,134人の女性を含む前向きなコホート研究 (国立衛生研究所-AARPダイエットと健康研究).
- 参加者はライフスタイルに関するアンケートに回答し,1995年から2006年まで追跡調査を行った.
- 以前のコホート研究の体系的なレビューと,固定効果モデルを用いた相対リスクのメタ分析.
主要な成果:
- フォローアップの450万人年以上にわたり,膀がんの症例は3896人の男性と627人の女性で発生しました.
- 現在の喫煙者は,決して喫煙していない人と比較して,膀がんのリスクが4.06倍 (HR=4.06) 増加しました.
- 喫煙に対する集団関連リスクは,男性では0.50,女性では0.52であり,このコホートでは,以前の研究と比較して相対的なリスクが高く見られた.
結論:
- 最近のNIH-AARPコホートでは,喫煙と膀がんの相対的なリスクは,1963年から1987年の米国データと比較して高くなっています.
- 喫煙に関連した膀がんの集団関連リスクは,このコホートにおける男性と女性の間で比較可能である.
- 研究結果は,喫煙が膀がんリスクに引き続き重大な影響を及ぼしていることを強調しています.
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