脊椎動物の進化の過程で,規制の革新が起こった3つの時期
Craig B Lowe1, Manolis Kellis, Adam Siepel
1Center for Biomolecular Science and Engineering, University of California, Santa Cruz, CA 95064, USA.
まとめ
遺伝子規制要素の進化は,異なるイノベーション期間を示しています. 発達遺伝子の近くでの初期の得点は,脊椎動物における細胞外信号伝達とタンパク質改変遺伝子へと移行した.
科学分野:
- 進化的ゲノミクスについて
- 遺伝子調節 遺伝子調節
- 脊椎動物の進化について
背景:
- 遺伝子調節要素の変化は,動物の系統にわたる現象型進化を駆動する.
- 規制要素の起源と進化を理解することは,進化過程の解読に極めて重要です.
研究 の 目的:
- 脊椎動物の進化を通じて遺伝子の調節要素の獲得を調査する.
- ゲノム全体にわたる,推定される規制領域のセットを特定し,その進化的起源を推論する.
主な方法:
- ヒトを含む5つの脊椎動物のゲノムにわたる推定的な規制領域として,保存されたノンソニック要素 (CNEEs) を特定しました.
- CNEEsが選択的制約の対象となった進化の枝を推論した.
主要な成果:
- 脊椎動物の進化過程における規制要素の革新の3つの異なる時期を発見した.
- 初期の脊椎動物の進化は,転写因子や発達遺伝子の近くで,規制的利益を示した.
- 後の時代には,細胞外信号伝達と翻訳後のタンパク質改変遺伝子の近くで革新が示されました.
結論:
- 遺伝子調節要素の進化は,それらが関連付けている遺伝子のタイプのダイナミックなシフトによって特徴付けられています.
- これらのシフトは,脊椎動物の系統における主要な進化的移行と適応を反映しています.
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