関連する実験動画

Updated: May 30, 2026

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
10:29

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors

Published on: May 9, 2025

HIV逆転転写酵素のTyr181Cys変種を標的とした強力な抗HIV剤の効率的な発見

William L Jorgensen1, Mariela Bollini, Vinay V Thakur

  • 1Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States. william.jorgensen@yale.edu

Journal of the American Chemical Society
|August 23, 2011
PubMed
まとめ

新しい非核糖逆転写酵素阻害剤 (NNRTIs) は,HIV-1耐性変異を克服する. コンピュータモデリングは,野生型と変異したHIV株の両方に有効な強力なNNRTIの設計を導きました.

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