血清カテープシンSと高齢者の死亡率との関連
Elisabeth Jobs1, Erik Ingelsson, Ulf Risérus
1Department of Public Health and Caring Sciences, Section of Geriatrics, Uppsala University, Uppsala, Sweden.
JAMA
|September 1, 2011
まとめ
血清カテープシンS濃度の上昇は,高齢者の死亡リスクの増加と関連しています. この発見は,キャセプシンSが年齢関連の疾患に役割を果たす可能性を示唆し,さらなる調査を正当化しています.
科学分野:
- バイオケミストリーと分子生物学
- ゲロントロジーはゲロントロジーの学科です.
- 心血管疾患に関する研究
背景:
- 実験データによると,システインプロテアゼであるキャセプシンSは,心血管疾患とがん経路に関与している.
- 現在,循環中のキャセプシンSレベルと死亡率との関連に関する見通しデータは限られている.
研究 の 目的:
- 血清カテープシンS濃度と死亡リスクとの関係を調べる.
- この関連性を,高齢の男性と女性の2つの独立したコホートで調査します.
主な方法:
- 大人男性に対するウプサラ長距離研究 (ULSAM) とウプサラ高齢者における血管系の将来の調査 (PIVUS) のコホートを利用した将来的研究設計.
- 血清のセプシンS濃度が測定され,全死亡率は延長されたフォローアップ期間中に追跡されました.
- 多変量コックス回帰モデルを使用し,多くの心血管疾患およびライフスタイルリスク要因を調整しました.
主要な成果:
- 血清カテープシンS濃度の上昇は,ULSAMとPIVUSの両方のコホートにおいて,あらゆる原因による死亡のリスクの増加と有意に関連していました.
- ULSAMコホートでは,キャセプシンSの上昇は,心血管疾患による死亡率と癌による死亡率の増加とも相関していた.
- ハザード比は,両コホートでキャセプシンS濃度が高くなり,死亡リスクが一貫して高まっていることを示した.
結論:
- 血清カテープシンS濃度の上昇は,高齢者の死亡リスクが高いと関連しています.
- カテプシンSの病気の病原性における正確な役割と,バイオマーカーとしての潜在的な臨床的有用性を明らかにするために,さらなる研究が必要である.
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