Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

33
Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within...
33
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

99
Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and...
99
Genomic DNA in Prokaryotes00:46

Genomic DNA in Prokaryotes

50.5K
The genome of most prokaryotic organisms consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the nucleoid. The chromosome is tightly wound, or supercoiled, for efficient storage. Prokaryotes also contain other circular pieces of DNA called plasmids. These plasmids are smaller than the chromosome and often carry genes that confer adaptive functions, such as antibiotic resistance.
Genomic Diversity in Bacteria
Although bacterial genomes are much...
50.5K
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

1.9K
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
1.9K
Antibiotic Selection00:57

Antibiotic Selection

62.1K
Overview
62.1K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

3.5K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
3.5K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

A natural depsipeptide antibiotic binds the E-site of the bacterial ribosome.

Nature·2026
Same author

Systemic Acquired Resistance signaling molecule N-hydroxypipecolic acid is involved in Age-Related Resistance in Arabidopsis thaliana.

Plant physiology·2026
Same author

The role of whole genome sequencing in antimicrobial susceptibility prediction of bacteria: 2025 update from the European Committee on Antimicrobial Susceptibility Testing Subcommittee.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2026
Same author

Ankh-Score Produces Better Sequence Alignments Than AlphaFold3.

Proteins·2026
Same author

Ngt-1: A glycosyltransferase that confers resistance to three distinct antibiotic classes.

The Journal of biological chemistry·2026
Same author

Permafrost landsystems define regional variability in climate change effects on northern environments.

Nature communications·2026

関連する実験動画

Updated: Mar 30, 2026

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

8.4K

抗生物質耐性は古くから存在しています.

Vanessa M D'Costa1, Christine E King, Lindsay Kalan

  • 1Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada, L8N 3Z5.

Nature
|September 2, 2011
PubMed
まとめ
この要約は機械生成です。

抗生物質耐性は自然現象であり,現代医学より前のものです. 古代のDNA分析は3万年前の永久凍土に多様な抵抗性遺伝子を発見し,現代の問題として抵抗性の見方に異議を唱える.

さらに関連する動画

Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance
09:00

Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance

Published on: May 2, 2018

12.5K
Screening Foodstuffs for Class 1 Integrons and Gene Cassettes
09:37

Screening Foodstuffs for Class 1 Integrons and Gene Cassettes

Published on: June 19, 2015

9.5K

関連する実験動画

Last Updated: Mar 30, 2026

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

8.4K
Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance
09:00

Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance

Published on: May 2, 2018

12.5K
Screening Foodstuffs for Class 1 Integrons and Gene Cassettes
09:37

Screening Foodstuffs for Class 1 Integrons and Gene Cassettes

Published on: June 19, 2015

9.5K

科学分野:

  • 微生物学 微生物学とは
  • 遺伝学 遺伝学とは
  • パレオゲノミクスとは

背景:

  • 抗生物質は医学に革命をもたらしたが,その使用には常に耐性菌の出現が伴っていた.
  • 病原性細菌における抗生物質耐性の出現は,しばしば現代的な現象と見なされます.
  • 抗生物質以前の時代の微生物のコレクションは,通常,抗生物質に対する高い感受性を表しています.

研究 の 目的:

  • 抗生物質耐性の歴史的起源を調査する.
  • 抗生物質の広範な臨床使用の前に抗生物質耐性遺伝子が存在していたかどうかを決定する.
  • 抗生物質耐性メカニズムの証拠を求めて古代DNAを分析する.

主な方法:

  • 古代DNAの標的化されたメタゲノム解析.
  • 3万年前のベリンジウム永久凍土の堆積物からDNAの抽出と分析.
  • バンコマイシン耐性要素VanAを含む,特定された耐性要素の構造と機能の研究.

主要な成果:

  • 古代DNAにおけるβ-ラクタム,テトラサイクリン,およびグリコペプチド抗生物質に対する耐性を付与する多様な遺伝子の識別.
  • 古代のヴァンコマイシン耐性元素ヴァンAが,構造的にも機能的にも現代の変種に似ていることを確認しました.
  • 抗生物質耐性遺伝子の存在が,抗生物質の時代より前に示された.

結論:

  • 抗生物質耐性は,進化の深い根源を持つ自然現象である.
  • 現代の抗生物質の広範な使用は,抗生物質耐性の唯一の要因ではありません.
  • 古代の微生物コミュニティは,抗生物質耐性のための洗練されたメカニズムを持っていた.