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Updated: May 29, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
10:44

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

BETブロモドメイン阻害は,c-Mycを標的とする治療戦略として用いられる

Jake E Delmore1, Ghayas C Issa, Madeleine E Lemieux

  • 1Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA.

Cell
|September 6, 2011
PubMed
まとめ

JQ1によるブロモドメイン阻害によるMYC転写をターゲットにすると,Myc依存遺伝子が効果的にダウンレギュレーションされます. このアプローチは,多発性骨髄腫およびMYCによって引き起こされる他のがんの治療に有望であることを示しています.

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