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Updated: May 29, 2026

Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities
11:44

Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities

Published on: October 2, 2018

安定したシスタチオニンブリッジを組み込んだα-Conotoxin ImIは,完全な効能と同一の3次元構造を維持します

Zoltan Dekan1, Irina Vetter, Norelle L Daly

  • 1Institute for Molecular Bioscience, The University of Queensland, St Lucia 4072, Queensland, Australia.

Journal of the American Chemical Society
|September 9, 2011
PubMed
まとめ

研究者らはα-コノトキシンIMIの二硫化結合を安定したチオエーテルで置き換えました. 1つのアナログは,α7ニコチンアセチルコリン受容体 (nAChR) で完全な反抗活性を維持し,薬物開発の可能性を示した.

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The Importance of Correct Protein Concentration for Kinetics and Affinity Determination in Structure-function Analysis19:16

The Importance of Correct Protein Concentration for Kinetics and Affinity Determination in Structure-function Analysis

Published on: March 17, 2010

A High-throughput-compatible FRET-based Platform for Identification and Characterization of Botulinum Neurotoxin Light Chain Modulators10:30

A High-throughput-compatible FRET-based Platform for Identification and Characterization of Botulinum Neurotoxin Light Chain Modulators

Published on: December 27, 2013

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