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HLA-DR分子との不変連鎖結合は,免疫原性ペプチド結合を阻害する

P A Roche1, P Cresswell

  • 1Department of Microbiology and Immunology, Duke University Medical Center, Durham, North Carolina 27710.

Nature
|June 14, 1990
PubMed
まとめ

インヴァリアント (I) 鎖は,ペプチドがヒト白血球抗原-DR (HLA-DR) 分子に輸送初期に結合するのを防ぐ. しかし,成熟したHLA-DR分子はペプチドを効果的に結合し,MHCクラスIおよびIIの分子の異なる機能を維持します.

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