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Updated: May 29, 2026

A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4
06:56

A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4

Published on: March 10, 2018

アロステリックアゴニストであるペプドゥチンとケモカイン受容体CXCR4の間の直接的な相互作用

Jay M Janz1, Yong Ren, Richard Looby

  • 1Anchor Therapeutics, Cambridge, Massachusetts 02142, United States. jjanz@anchortx.com

Journal of the American Chemical Society
|September 13, 2011
PubMed
まとめ

研究者は,ペプドゥチンがGタンパク質結合受容体 (GPCRs) とどのように相互作用するかを研究するために,フォトクロスリンク方法を開発しました. この技術は,ATI-2341がケモカインC-X-C型受容体4 (CXCR4) に直接結合することを確認し,新しいアロステル調節機構を明らかにしました.

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Optimizing the Genetic Incorporation of Chemical Probes into GPCRs for Photo-crosslinking Mapping and Bioorthogonal Chemistry in Live Mammalian Cells14:02

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