双管大動脈弁を有する患者における大動脈合併症の発生率
Hector I Michelena1, Amber D Khanna, Douglas Mahoney
1Division of Cardiovascular Disease, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA. michelena.hector@mayo.edu
JAMA
|September 16, 2011
まとめ
双管大動脈弁 (BAV) の患者では大動脈解剖の発生率は低いが,一般人よりも著しく高い. 長期データによると,BAV患者では大動脈動脈瘤と手術のリスクが増加しています.
科学分野:
- 心臓病学 心臓病学
- 遺伝学 遺伝学とは
- 公衆衛生は公衆衛生である.
背景:
- 二動脈弁 (BAV) は,最も一般的な先天性心不全です.
- BAV患者における大動脈合併症に関する長期的な集団ベースのデータは限られている.
研究 の 目的:
- BAV患者における大動脈合併症の発生率を決定する.
- これらの発生率を一般人口と比較するために.
主な方法:
- BAVと診断されたオルムステッド郡の住民 (1980年-1999年) の遡及的なコホート研究.
- 長期フォローアップ (2008年~2009年までの) では,胸部大動脈解剖,上昇大動脈動脈瘤,大動脈外科手術を評価した.
- 診断されたBAVと未診断のBAV患者を含む.
主要な成果:
- BAV患者における大動脈解剖の発生率は1万患者年あたり3.1であり,一般人よりも8.4倍高い.
- 昇動性大動脈動脈瘤の発生率は1万患者年当たり84.9であり,一般人口の86.2倍であった.
- 25年間の大動脈外科手術率は,BAV患者で25%でした.
結論:
- BAV患者における大動脈解剖の発生率は低いが,一般の人々と比較して著しく上昇している.
- BAVの患者は大動脈動脈瘤を発症し,大動脈外科手術を必要とするリスクが大幅に増加します.
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