ピリフォームドニューロンの集合体で対極的な行動を誘導する
Gloria B Choi1, Dan D Stettler, Benjamin R Kallman
1Department of Neuroscience and the Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Cell
|September 20, 2011
まとめ
ピリフォームム皮質は,感覚の入力なしに,学習した行動を生成することができます. 特定のニューロングループが活性化され,報酬やショックとペアリングされると,異なる行動反応を誘発し,皮質を証明します.
科学分野:
- 神経科学は神経科学である.
- 嗅覚系の研究 嗅覚系の研究
- 行動神経科学は,行動神経科学である.
背景:
- 嗅覚に不可欠なピリフォームム皮質は,匂いを表現するために感覚の入力を必要とすると考えられていた.
- 既存のモデルは,匂いの重要性を経験を通して学ぶことを示唆しています.
研究 の 目的:
- 特定のピリフォームド皮質ニューロン集団を活性化することで,感覚の入力なしに学習された行動を誘発できるかどうかを調査する.
- 異なるニューロン亜集団が独立して制御され,異なる学習反応を誘発できるかどうかを判断する.
主な方法:
- ネズミにおけるチャネルロドプシン発現 (ChR2) のピリフォームド皮質ニューロンの光遺伝的活性化.
- ニューロンの活性化を食欲 (報酬) または嫌悪性 (ショック) の刺激とペアリングする.
- 異なる行動出力の異なるニューロンのサブ集団を差別し,誘導する能力をテストする.
主要な成果:
- ピリフォームド皮質の神経細胞の特定のサブ集団の活性化は,報酬やショックと組み合わせると,食欲や嫌悪的な行動を確実に誘発します.
- 異なるニューロンのサブ集団が独立して制御され,異なる学習された行動を生成することを示した.
- ピリフォームム皮質は,同時に感覚刺激を受けることなく,学習された行動的アウトプットを生成するのに十分であることを示した.
結論:
- ピリフォームド皮質は,直接的な感覚入力とは独立して学習された行動的出力を生成することができます.
- 学習された嗅覚行動は,特定のピリフォームド皮質ニューロン集合体の標的型活性化によって誘発される可能性があります.
- これらの発見は,ピリフォームド皮質が匂いのアイデンティティと行動的出力マッピングのための空間的組織にのみ依存するモデルに挑戦しています.
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