(±) -ストレプトニグリンの全合成:リング閉鎖メタテシスを用いてペンタス置換ピリジンのデノボ構築

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Updated: May 29, 2026

Solid-phase Synthesis of [4.4] Spirocyclic Oximes
05:15

Solid-phase Synthesis of [4.4] Spirocyclic Oximes

Published on: February 6, 2019

Timothy J Donohoe1, Christopher R Jones, Luiz C A Barbosa

  • 1Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK. Timothy.donohoe@chem.ox.ac.uk

Journal of the American Chemical Society
|September 28, 2011
PubMed
まとめ

研究者は14段階のプロセスを用いて強力な抗腫瘍剤 (±) - ストレプトニグリンを合成しました. この新しい合成は,新しいがん治療の開発に不可欠な,重要なペンタスブスティュートされたピリジン断片を提供します.

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