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Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
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1型糖尿病患者における心筋の構造,機能,および傷跡
Evrim B Turkbey1, Jye-Yu C Backlund, Saul Genuth
1National Institutes of Health Clinical Center, National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD 20892, USA.
Circulation
|September 28, 2011
まとめ
1型糖尿病における高血糖と腎臓の合併症は,心臓の構造の変化と傷痕組織に関連しています. これらの発見は,糖尿病患者の主要な心血管疾患リスクを強調しています.
科学分野:
- 心臓病学 心臓病学
- エンドクリノロジー エンドクリノロジー
- 糖尿病学 糖尿病学
背景:
- 1型糖尿病 (T1DM) は,心血管疾患 (CVD) のリスクの増加と関連しています.
- T1DMが心臓の構造と機能に与える影響を理解することは,リスクの階層化に不可欠です.
- DCCT/EDICの研究は,これらの関係を調査するためのユニークな長期コホートを提供します.
研究 の 目的:
- T1DM患者におけるCVDリスク因子と心筋膜の構造,機能,および傷痕との関連を調べる.
- T1DMにおける心臓の変化に寄与する特定の危険因子を特定する.
- このT1DMコホートにおける心筋の有病率を評価する.
主な方法:
- 心臓磁気共鳴画像 (CMR) は1017人のT1DM患者で実施されました.
- ガドリニウム強化CMRは741人の患者で得られた.
- 線形およびロジスティック回帰モデルは,CVDリスク因子とCMRパラメータの関連性を分析しました.
主要な成果:
- マクロアルブミヌーリアは左心室の質量増加と,左心室の質量と終盤のダイアストリック体積の比率の高さに関連していた.
- 22年以上にわたる平均ヘモグロビンA1cの上昇は,末期ダイアストリック容量および脳卒中容量の減少,および左心室質量対末期ダイアストリック容量の比率の増加と関連していました.
- 心筋痕の有病率は,CMRによって4.3%であった;マクロアルブミヌーリアと平均ヘモグロビンA1cの上昇は,心筋痕と有意に関連していた.
結論:
- 平均ヘモグロビンA1cの上昇とマクロアルブミヌーリアは,T1DMにおける心臓の構造的および機能的変化の有意な予測要因です.
- これらの要因は,従来のCVDリスク要因を超えて,心筋臓の健康に影響を与えます.
- この研究では,比較的腎臓機能が保たれたT1DM患者において,心筋の有病率は4.3%であった.
関連する概念動画
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