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Updated: May 28, 2026

An Acetyl-Click Chemistry Assay to Measure Histone Acetyltransferase 1 Acetylation
05:44

An Acetyl-Click Chemistry Assay to Measure Histone Acetyltransferase 1 Acetylation

Published on: January 26, 2024

イテラティブ・イン・シット・クリック・ケミストリーは,Akt1に対する分岐捕獲剤とアロステリック阻害剤を組み立てます

Steven W Millward1, Ryan K Henning, Gabriel A Kwong

  • 1Nanosystems Biology Cancer Center, Division of Chemistry and Chemical Engineering, MC-127-72, California Institute of Technology, Pasadena, California 91125, United States.

Journal of the American Chemical Society
|October 4, 2011
PubMed
まとめ

研究者らは,Akt特異抗体置換として,イテレティブ・イン・シット・クリック・ケミストリーを使用して,新しいペプチド・トライガンドを設計した. この強力なリガンドは,Aktを効率的に免疫的に誘導し,新たな抑制特性を持つ可能性を示しています.

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