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Updated: May 28, 2026

Assessing Cellular Target Engagement by SHP2 (PTPN11) Phosphatase Inhibitors
08:45

Assessing Cellular Target Engagement by SHP2 (PTPN11) Phosphatase Inhibitors

Published on: July 17, 2020

形状感知抗体は,PTP1Bの酸化形態を安定させ,そのフォスファターゼ活性を抑制する

Aftabul Haque1, Jannik N Andersen, Annette Salmeen

  • 1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

Cell
|October 4, 2011
PubMed
まとめ

研究者らは,タンパク質チロシンフォスファタゼ1B (PTP1B) の非活性形態を安定させるための新しい抗体を開発し,インスリンシグナル伝達を強化することで,糖尿病と肥満に対する新しい治療戦略を提供しました.

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