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Updated: May 28, 2026

Artificial RNA Polymerase II Elongation Complexes for Dissecting Co-transcriptional RNA Processing Events
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CTCFが促進するRNAポリメラーゼIIの停止は,DNAメチル化とスプライシングを結びつける

Sanjeev Shukla1, Ersen Kavak, Melissa Gregory

  • 1Center for Cancer Research, Mouse Cancer Genetics Program, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA.

Nature
|October 4, 2011
PubMed
まとめ

CCCTC結合因子 (CTCF) タンパク質は,RNAポリメラーゼIIの停止を調節することによって,代替スプライシングに影響を与えます. DNAメチル化は,CTCF結合を変化させ,エクソン含有に影響を与え,スプライシングの結果に対する表遺伝的制御を提供することができます.

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