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身体活動の関連性は,血管内皮機能とインティマ・メディアの厚さと関連している

Katja Pahkala¹, Olli J Heinonen, Olli Simell

¹University of Turku, Research Centre of Applied and Preventive Cardiovascular Medicine, FI-20520 Turku, Finland. katja.pahkala@utu.fi

|October 5, 2011

まとめ

青少年における定期的な身体活動は,血管の健康を改善し,内皮機能を強化し,インティマ・メディアの厚さ (IMT) を減少させます. 活動量の適度な増加でさえ,動脈硬化マーカーの進行を著しく遅らせる可能性があります.

科学分野:

心血管の健康についてです.
青春期医療について
予防性心臓病学予防性心臓病学

背景:

アテロゲネシスは,内皮機能不全とインティマ・メディアの厚さ (IMT) の増加から始まります.
青年の血管健康に身体活動の影響に関する縦断的なデータは限られている.

研究の目的:

健康な青少年におけるレジャー時間の身体活動と内皮機能 (フロー・メディエイト・ディラレーション,FMD) と大動脈のIMTとの関連性を将来的に調査する.

主な方法:

縦断的な研究では,13歳から17歳までの553人の青少年が追跡されました.
血管のパラメータ (FMD,IMT) は,超音波検査で測定されました.
休憩時間の身体活動は,週1時間分の代謝同値 (MET) を用いて定量化されました.

主要な成果:

身体活動は,内皮機能 (最大口腔炎,総口腔炎応答) と直接関連しており,IMTと逆関連を示した.
身体活動を増やした青年は,静止状態の仲間と比較して,口腔炎の改善とIMTの進行の減少を示した.
持続的に活動的な若者は,静止状態になった若者と比較して,IMTの進行を弱めた.

結論:

身体活動は,青少年における内皮機能とIMTと好意的に関連しています.
身体活動の適度な増加は,IMTの進行を減少させます.
アクティブなライフスタイルは,青少年における亜臨床的動脈硬化変化を予防することができます.

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