分泌された真菌効果因子によってメタボリックプライミングが行われます
Armin Djamei1, Kerstin Schipper, Franziska Rabe
1Max Planck Institute for Terrestrial Microbiology, Karl-von-Frisch-Straße 10, D-35043 Marburg, Germany.
Nature
|October 7, 2011
まとめ
ウスティラゴ・メイディスは,真菌の毒性因子であるコリスマートミュータゼCmu1を分泌する. この酵素は,植物細胞の代謝状態を変更することによって,トウモロコシのスムート発達のための植物細胞を原始化します.
科学分野:
- 植物病理学 植物病理学
- 菌類学 菌類学とは
- バイオケミストリー バイオケミストリー
背景:
- ウスティラゴ・メイディス (Ustilago maydis) によって引き起こされるトウモロコシの汚れは,重要な農業病です.
- U. maydisは,分泌されるエフェクタータンパク質を通じて宿主植物を操作するバイオトロフな真菌です.
- 菌類は,効果因子の大きなレパートリーを持ち,その多くは未知の機能を持っています.
研究 の 目的:
- 潜在的ウイルス性因子としてのU. maydis chorismate mutase (Cmu1) の役割を調査する.
- Cmu1が宿主植物細胞に影響を与えるメカニズムを理解する.
主な方法:
- 潜在的毒性の要因を特定するために,U. maydis secretomeの分析.
- 宿主植物相互作用におけるCmu1の機能の実験的検証.
- Cmu1で治療された植物細胞の細胞吸収と代謝分析.
主要な成果:
- U. maydisは,植物細胞に吸収されるコリスマートミュータゼCmu1を分泌する.
- Cmu1は隣接する植物細胞に広がり,代謝原始化を誘発する.
- この代謝の変化は,真菌の毒性を高めます.
結論:
- Cmu1はU. maydisの毒性の要因であり,トウモロコシのスムート発達の促進をします.
- 分泌されるコリスマート変異は,植物に関連した微生物による宿主操作のための保存された戦略を表しています.
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