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Updated: May 28, 2026

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
10:51

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists

Published on: November 15, 2013

人間のアリル炭化水素受容体の内生性腫瘍促進リガンドである

Christiane A Opitz1, Ulrike M Litzenburger, Felix Sahm

  • 1Department of Neurooncology, Neurology Clinic and National Center for Tumor Diseases, University Hospital of Heidelberg, 69120 Heidelberg, Germany.

Nature
|October 7, 2011
PubMed
まとめ

研究者らは,トリプトファン (Trp) の代謝産物であるキヌレニン (Kyn) を,アリル炭水化物受容体 (AHR) の内生リガンドとして特定した. このTDO-AHR経路は,腫瘍の成長と免疫抑制を促進し,がんの進行に影響を与えます.

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