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熱安定化D-アミノ酸置換物の計算設計

Agustina Rodriguez-Granillo1, Srinivas Annavarapu, Lei Zhang

  • 1Department of Biochemistry, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey (UMDNJ) and Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey 08854, USA.

Journal of the American Chemical Society
|October 8, 2011
PubMed
まとめ

D-アミノ酸をタンパク質に組み込むことは,安定性と機能を高めます. Trp-ケージのD-Glnのような特定の置換は,好ましい分子相互作用を通じてタンパク質の熱安定性を大幅に高めます.

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