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Updated: May 28, 2026

Structural Biology and Analytical Chemistry Approaches for Characterizing C-Glycoside Metabolic Enzymes in Human Gut Microbiota
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活性サイト改造は,二機能フルクトーゼ-1,6-ビスホスファートアルドラーゼ/フォスファタゼで実施されます

Juan Du1, Rafael F Say, Wei Lü

  • 1Lehrstuhl für Biochemie, Institut für organische Chemie und Biochemie, Albert-Ludwigs-Universität Freiburg, Albertstrasse 21, 79104 Freiburg, Germany.

Nature
|October 11, 2011
PubMed
まとめ

この研究は,二機能性果糖-1,6-ビスホスファート (FBP) アルドラーゼ/フォスファターゼ酵素が,その活性部位を改造して,2つの重要なグルコネオゲネシス反応を触媒化する方法を明らかにしています. 構造のスナップショットは,連続したMg2+結合とループの動きを示し,この先祖酵素を可能にします.

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