妊娠中の葉酸のサプリメントと,子供の重度の言語遅延
Christine Roth1, Per Magnus, Synnve Schjølberg
1Division of Mental Health, Norwegian Institute of Public Health, PO Box 4404, Nydalen, 0403 Oslo, Norway. christine.roth@fhi.no
JAMA
|October 13, 2011
まとめ
妊婦が妊娠初期に葉酸サプリメントを使用すると,子どもに重度の言語遅延のリスクが低いことが示されました. この発見は,胎児前葉酸が子供の神経発達に与える恩恵を裏付けている.
科学分野:
- 神経発達に関する研究.
- 母親と子供の健康について
- 栄養科学とは,栄養科学である.
背景:
- 産前葉酸は,神経管欠陥のリスクを減らすことが知られている.
- 葉酸は,他の神経発達上の結果に肯定的な影響を与える可能性があります.
- 言語発達に影響を与える人生の初期段階の要因を理解することは極めて重要です.
研究 の 目的:
- 妊婦の胎児前葉酸サプリメント使用と3歳児の重度の言語遅延との関連を調査する.
- 妊娠前のサプリメント摂取の異なるパターンに基づいて,言語遅延のリスクを定量化するために.
主な方法:
- ノルウェーの母子コホートに関する見通しの観察研究.
- 2008年以前に生まれた母親と子供のデータを含め,3歳のフォローアップを行った.
- ロジスティック回帰分析は,葉酸曝露のタイミングに基づいて,重度の言語遅延の確率比を推定しました.
主要な成果:
- 38,954人の子供のうち,0.5%が重度の言語遅延を経験しました.
- 母の葉酸のみのサプリメントは,リスクの低下を示した (OR,0.55;95%CI,0.35-0.86).
- 葉酸と他のサプリメントの組み合わせもリスクの低下を示した (OR,0.55;95%CI,0.39-0.78).
結論:
- 妊娠初期における母子の葉酸補給は,重度の言語遅延のリスクの低下と関連しています.
- これらの発見は,胎児の言語発達に対する胎児前葉酸の重要性を強調しています.
- この研究は,神経管の欠陥の予防を超えて,葉酸の役割を支持する証拠を提供します.
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