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Updated: May 28, 2026

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors
12:40

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors

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Bcr-AblのSH2-キナーゼインターフェースをターゲットにすることで,白血病発生を抑制します

Florian Grebien1, Oliver Hantschel, John Wojcik

  • 1Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.

Cell
|October 18, 2011
PubMed
まとめ

Bcr-Abl SH2-キナーゼインターフェースをターゲットにすることで,慢性骨髄性白血病 (CML) のシグナル伝達が妨げられ,マウスの白血病が根絶されます. このアロステリックアプローチは,耐性CMLにおけるチロシンキナーゼ阻害剤 (TKI) に対する感受性を高めます.

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