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非正規の炎症ホルモンの活性化は,カスパース-11を標的とする

Nobuhiko Kayagaki1, Søren Warming, Mohamed Lamkanfi

  • 1Department of Physiological Chemistry, Genentech Inc., South San Francisco, California 94080, USA. kayagaki@gene.com

Nature
|October 18, 2011
PubMed
まとめ

カスパース-11は,カスパース-1を活性化し,IL-1β.を生成することによって,細菌感染に対する先天性免疫応答を起動するために不可欠です. カスパース-11の喪失は,マウスを致命的なエンドトキシンショックから保護する.

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