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Updated: May 28, 2026

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

SUMOylation-defectiveのMITF生殖線変異は,メラノーマと腎臓がんの発生を誘発する

Corine Bertolotto1, Fabienne Lesueur, Sandy Giuliano

  • 11] INSERM, U895 (équipe 1), Equipe labélisée Ligue Contre le Cancer, C3M, 06204 Nice, France [2] Université of Nice Sophia-Antipolis, UFR Médecine, 06204 Nice, France [3] Centre Hospitalier Universitaire de Nice, Service de Dermatologie, 06204 Nice, France [4].

Nature
|October 21, 2011
PubMed
まとめ

マイクロフタルミア関連転写因子 (MITF) 遺伝子であるMi-E318Kの遺伝子変異は,メラノーマおよび腎臓細胞癌 (RCC) の発症リスクを大幅に増加させます. この発見は,この2つの癌に対する共通の遺伝的傾向を示唆しています.

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Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model12:37

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