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関連する概念動画

Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
Nucleic Acid Structure01:25

Nucleic Acid Structure

The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA has a double-helix structure. The...
Protein Folding01:25

Protein Folding

Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...
Cooperative Binding of Transcription Regulators02:13

Cooperative Binding of Transcription Regulators

Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome.  Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form dimers that...
Conserved Binding Sites01:49

Conserved Binding Sites

Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally analyses the...

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Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
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合成マクロ分子における配列認識の適合調節

Zhixue Zhu1, Christine J Cardin, Yu Gan

  • 1Department of Chemistry, University of Reading, Whiteknights, Reading RG6 6AD, United Kingdom. zhixue.zhu.rdg@googlemail.com

Journal of the American Chemical Society
|October 25, 2011
PubMed
まとめ

異なったエーテル-ケトンおよびエーテル-スルフォン結合を持つ芳香性コポリミドは,ピレンベースのピンチ分子に対して明確な結合親和性を示す. これらの差異は,二次的なπ-π-スタッキング相互作用に影響を与える形状の変化から生じる.

さらに関連する動画

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
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Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

Published on: September 21, 2017

Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells
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Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells

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関連する実験動画

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Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
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科学分野:

  • ポリマー化学のポリマー化学について
  • 超分子化学 超分子化学
  • マテリアルサイエンス 材料科学

背景:

  • 高分子量アロマティックコポリイミドは,ピロメリチミド単位を特徴とする.
  • これらの単位は,エーテル-ケトン (K) またはエーテル-スルフォン (S) の残留物で囲まれており,KIK,KIS,SISのようなトリプルセット配列を形成します.
  • ピレン基のピンセート分子はこのポリマーに π-π スタッキングと水素結合で結合する.

研究 の 目的:

  • 異なる芳香コポリイミドトリプレート配列に対するピレンベースのピンチ分子との結合強度の違いを調査する.
  • これらの結合親和性を支配する分子メカニズムを解明する.
  • コポリイミドの構造特性を結合能力と相関させる.

主な方法:

  • 複雑化シフトを測定するための核磁共振 (NMR) スペクトロスコーピー.
  • ピンチ-ポリマー結合定数の決定.
  • ピンチとポリマーの相互作用のコンピューティングモデリング.
  • ピンチ・コンプレックスにおける単一結晶X線 difraktion分析.

主要な成果:

  • 拘束力は次の順に順番付けられています: SIS > KIS > KIK.
  • (1) H NMRの複合シフトと結合定数は,これらの差異を定量化します.
  • 計算モデルとX線結晶学により,ダイアリルケトンとダイアリル硫の結合における構造的偏好が重要なことが明らかになった.
  • これらの好みは,チェーン折りや二次 π-π スタッキングの発生を決定する.

結論:

  • エーテル・ケトンおよびエーテル・スルフォン結合におけるアロマティックリングの構造的柔軟性は,ピンチ・分子結合に大きく影響する.
  • 二次的π-π-スタッキング相互作用は,観察された結合強さの変動において重要な役割を果たします.
  • これらの構造-特性関係を理解することで,高度な超分子材料の設計が可能になります.