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Updated: May 28, 2026

Assessment of Long-term Depression Induction in Adult Cerebellar Slices
09:30

Assessment of Long-term Depression Induction in Adult Cerebellar Slices

Published on: October 16, 2019

電気シナプスの活動に依存した長期抑うつ

Julie S Haas1, Baltazar Zavala, Carole E Landisman

  • 1Children's Hospital, Department of Neurology, Harvard University, 300 Longwood Avenue, Boston, MA 02115, USA. julie.haas@gmail.com

Science (New York, N.Y.)
|October 25, 2011
PubMed
まとめ

研究者らは,タラミック網膜核 (TRN) のニューロンで調整された突発発射が電気シナプスを弱める可能性があることを発見しました. 神経活動の方向に特異的なこの使用依存の可塑性は,ダイナミックなネットワークの再編成のメカニズムを示唆しています.

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Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation09:39

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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
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Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
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