不眠症と急性心筋梗塞のリスク:集団研究

Lars E Laugsand¹, Lars J Vatten, Carl Platou

¹Department of Public Health, Faculty of Medicine, Trondheim, Norway. lars.e.laugsand@ntnu.no

Circulation

|October 26, 2011

まとめ

睡眠障害や回復不可能な睡眠などの不眠症の症状は,急性心筋梗塞 (AMI) のリスクを適度に高めます. この関連性は,投与量に依存しており,分析全体で堅調でした.

科学分野:

心臓病学心臓病学
スリープ・メディシン (睡眠医学)
エピデミオロジーエピデミオロジー

背景:

不眠症と冠動脈疾患のリスクに関する見通し調査は限られている.
不眠症は,潜在的に心血管的影響を及ぼす一般的な睡眠障害です.

研究の目的:

不眠症の症状と急性心筋梗塞 (AMI) のリスクとの関連を調べる.
不眠症の症状頻度とAMIリスクの間の用量依存関係を評価する.

主な方法:

52,610人の参加者を対象とした大規模な集団ベースのコホート研究です.
病院記録と死亡記録を用いて,11.4年以上にわたるインシデントAMIの追跡調査.
多くの心血管リスク要因とライフスタイル変数に調整された多変量分析.

主要な成果:

睡眠開始の困難,睡眠の維持,および回復しない睡眠を含む不眠症の症状は,AMIリスクの適度な増加と関連していました.
不眠症の症状の数とAMIリスク (P for trend = 0.003) の間には,用量依存の関連性が見られた.
睡眠開始の困難は,AMIリスクと特に強い関連性を示した (HR=1.45).

結論:

不眠症は,急性心筋梗塞の重要な危険因子です.
不眠症の症状に対処することは,心血管疾患の予防戦略にとって重要かもしれません.

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