天然のアリル炭化水素受容体リガンドは,腸内リンパ性毛囊のオーガノゲネシスを制御する
Elina A Kiss1, Cedric Vonarbourg, Stefanie Kopfmann
1Institute of Medical Microbiology and Hygiene, University of Freiburg Medical Center, Freiburg, Germany.
Science (New York, N.Y.)
|October 29, 2011
まとめ
Brassicaceaeの野菜のような栄養素は,先天性リンパ性細胞 (ILC) のアリル炭水化物受容体 (AhR) を活性化します. このAhRシグナル伝達は,腸内リンパ性卵泡を形成し,感染症に対する腸内免疫を維持するために不可欠です.
科学分野:
- 免疫学 免疫学とは
- 微生物学 微生物学とは
- 栄養科学 栄養学 栄養科学は,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学は,栄養学が,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は
背景:
- RORγtを発現する先天性リンパ性細胞 (ILC) は,腸内ホメオスタシスとリンパ性卵泡形成に不可欠です.
- アリル炭化水素受容体 (AhR) は,環境的課題への適応に関与する保存された転写因子である.
研究 の 目的:
- RORγt (((+) ILCの発展と機能におけるAhRの役割を調査する.
- 食事成分がILCにおけるAhR活性を調節し,腸内免疫に影響を与えるかどうかを判断する.
主な方法:
- AhR欠乏マウスモデルを利用した.
- ダイエットリガンド,特にブラシカセイ (Brassicaceae) の野菜の影響を研究した.
- Citrobacter rodentiumの感染に対する感受性の評価.
主要な成果:
- AhRは,RORγt (((+) ILCの産後拡張と腸リンパ性葉っぱの発達に不可欠です.
- Brassicaceaeの野菜にあるようなダイエット用リガンドは,RORγt (((+) ILCにおけるAhR活動を誘導することができます.
- AhR欠乏したマウスは,Citrobacter rodentiumの感染に対する感受性の増加を示した.
結論:
- 食事中の栄養素と腸内免疫系の発達との間の分子結合を確立する.
- RORγt (((+) ILCにおけるAhRシグナル伝達が,腸内ホメオスタシスと感染抵抗性の維持に果たす重要な役割を強調する.
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