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Updated: May 28, 2026

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
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構造ベースの合理的設計を使用して,HIV抗体の効能と幅を増加させる

Ron Diskin1, Johannes F Scheid, Paola M Marcovecchio

  • 1Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.

Science (New York, N.Y.)
|October 29, 2011
PubMed
まとめ

CD4結合部位を標的とした強力なHIV-1抗体を設計した. 構造的な洞察は,中和の幅と効力を高める修正を明らかにし,効果的なHIV-1ワクチンのための将来の免疫原体の設計を導く.

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