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Updated: May 28, 2026

Silencing of BRCA2 to Identify Novel BRCA2-regulated Biological Functions in Cultured Human Cells
09:24

Silencing of BRCA2 to Identify Novel BRCA2-regulated Biological Functions in Cultured Human Cells

Published on: August 12, 2015

BRCA1腫瘍抑制は,BRCTフォスフォプロテイン結合に依存するが,そのE3リガース活性には依存しない

Reena Shakya1, Latarsha J Reid, Colleen R Reczek

  • 1Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA.

Science (New York, N.Y.)
|October 29, 2011
PubMed
まとめ

乳がん遺伝子1 (BRCA1) タンパク質のE3ユビキチンリガース活性が腫瘍抑制に不可欠ではない. 代わりに,BRCA1のBRCTドメインは,フォスフォタンパク質を認識し,癌を予防するために不可欠です.

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