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水素過酸化物を誘導するDNAクロスリンク剤:標的型抗がん前薬

Yunyan Kuang1, Kumudha Balakrishnan, Varsha Gandhi

  • 1Department of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, 3210 North Cramer Street, Milwaukee, Wisconsin 53211, USA.

Journal of the American Chemical Society
|November 1, 2011
PubMed
まとめ

研究者らは,がん細胞の活性酸素種 (ROS) によって活性化される新しい窒素マスタード前薬を開発した. これらのROS活性化抗がん剤は,正常な細胞に対する最小限の毒性で,がん細胞に対して高い有効性を示しています.

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