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Updated: May 28, 2026

Localization of Plasma Membrane and Intracellular Neuronal Nicotinic Acetylcholine Receptors Using Quantitative Imaging in Mammalian Cells
09:06

Localization of Plasma Membrane and Intracellular Neuronal Nicotinic Acetylcholine Receptors Using Quantitative Imaging in Mammalian Cells

Published on: December 19, 2025

神経毒素IIは,ダイナミックな核極化NMRによって研究された原生膜のアセチルコリン受容体と結合する

Arne H Linden1, Sascha Lange, W Trent Franks

  • 1Leibniz-Institut für Molekulare Pharmakologie (FMP), Robert-Rössle-Str. 10, 13125 Berlin, Germany.

Journal of the American Chemical Society
|November 2, 2011
PubMed
まとめ

この研究は,ニコチンアセチルコリン受容体 (nAChR) のような膜タンパク質の構造分析のためのダイナミック核偏振 (DNP) NMRを,浄化なしで実証しています. 最適化されたビラジカル分布は,ネイティブ膜における受容体-リガンド相互作用を研究するための感受性を高めます.

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