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トリプトファンハロゲナスを再設計して,直接的なアルカロイド前駆体である塩素を優先的に塩素化します

Weslee S Glenn1, Ezekiel Nims, Sarah E O'Connor

  • 1Department of Biological Chemistry, The John Innes Centre, Norwich NR4 7UH, UK.

Journal of the American Chemical Society
|November 5, 2011
PubMed
まとめ

設計されたフラビン依存ハロゲナーゼRebH (Y455W) は,アルカロイドの前駆体であるトリプタミンを選択的に塩素化します. このエンジニアリングされた酵素は,植物に不要な副産物を蓄積することなく,ハロゲン化されたアルカロイドの生体内生産を可能にします.

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