超安定性,再分散性,小型性,および高度に有機改変されたメソポラスシリカナノセラピュティクス
Yu-Shen Lin1, Nardine Abadeer, Katie R Hurley
1Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Journal of the American Chemical Society
|November 5, 2011
まとめ
安定し,再分散可能なメソポラスシリカナノ粒子は,生物医学的な使用のために,集積の問題を克服します. これらの小さなナノ粒子は低毒性を示し,効果的にドクソルビシンを投与し,がん細胞治療を強化します.
科学分野:
- ナノテクノロジー ナノテクノロジー
- マテリアルサイエンス 材料科学
- バイオメディカルエンジニアリング
背景:
- メソポラスシリカナノ粒子 (MSN) は,生物学的環境で集積の課題に直面し,その実用的な生物医学的な応用を制限しています.
- 不十分な分散性と安定性は,薬物投与およびその他のin vivo使用におけるMSNsの有効性を阻害します.
研究 の 目的:
- バイオメディカルアプリケーションの改善のために,高度に安定し,再分散可能なメソポラスシリカナノ粒子を開発する.
- 生物学的媒介におけるMSNsの劣った粒子の分散と不可逆的な集積の制限に対処するために.
主な方法:
- 小型のMSNの合成は,水熱処理と二重オルガノシランの表面改変によるものです.
- TEM,XRD,N2アドソルプション-デソルプション,DLS,ゼータポテンシャル,固体29Si NMRを含むテクニックを用いた特徴付け.
- シミュレートされた体液における安定性,乾燥後の再分散性,および in vitro 毒性試験の評価.
主要な成果:
- 合成されたMSNは,シミュレートされた体液に優れた安定性を示し,乾燥し,簡単に再分散することができ,15日以上サイズを維持しました.
- 製法方法は,光および磁性MSNの作成に適応できます.
- インビトロアッセイでは,毒性が最小で,ドクソルビシンに負荷されたMSNは,HeLa細胞に対する強化された細胞毒性を示した.
結論:
- 高度な安定性と再分散性のMSNは,生物医学アプリケーションにおける集積問題を克服するための有望な解決策を提供します.
- これらのナノ粒子は,水溶性および水溶性の低い薬剤の両方を効果的にロードし,投与することができ,治療効果が向上します.
- 開発されたMSNsは,標的がん治療を含む,将来のin vivo生物医学アプリケーションの有意な可能性を示しています.
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