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Updated: May 27, 2026

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
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ケトステロイドイソメラーゼにおけるオキシアニオンホールからの触媒的貢献の評価

Jason P Schwans1, Fanny Sunden, Ana Gonzalez

  • 1Department of Biochemistry, Stanford University, Stanford, California 94305, USA.

Journal of the American Chemical Society
|November 8, 2011
PubMed
まとめ

ケトステロイドイソメラーゼ (KSI) のオキシアニオンホールを変化させることで,その触媒的役割が明らかになる. 水溶液の相互作用を模倣した変異は,より小さな速度減少を示し,文脈に依存する水素結合の貢献を示した.

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