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Updated: May 5, 2026

Analysis of Group IV Viral SSHHPS Using In Vitro and In Silico Methods
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HIV-1の制限因子SAMHD1は,デオキシヌクレオシドトリホスファートトリホスフォヒドローラゼである

David C Goldstone1, Valerie Ennis-Adeniran, Joseph J Hedden

  • 1Division of Molecular Structure, MRC National Institute for Medical Research, London NW7 1AA, UK.

Nature
|November 8, 2011
PubMed
まとめ

人間のSAMHD1タンパク質は,デオキシヌクレオシドトリフォスファート (dNTP) を分解することによって,HIV-1の複製を制限する. これは,ミエロイド細胞におけるウイルスのDNA合成を阻害し,アイカルディ・グーティエール症候群の洞察を提供している.

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