脆弱性は,STセグメントの上昇ではない心筋梗塞の高齢患者の短期的なアウトカムと独立して関連しています
Niklas Ekerstad1, Eva Swahn, Magnus Janzon
1Center for Medical Technology Assessment/IMH, Linköping University, Sandbäcksgatan 7, 58183 Linköping, Sweden. niklas.ekerstad@liu.se
Circulation
|November 9, 2011
まとめ
脆弱性は,非STセグメント上昇心筋梗塞のために入院した高齢者の短期死亡率と不良結果を大幅に増加させます. 脆弱性の評価は,これらの脆弱な心血管疾患患者のリスクを予測するために重要です.
科学分野:
- ゲロントロジーはゲロントロジーの学科です.
- 心臓病学 心臓病学
- クリニカル・メディシン 臨床医学
背景:
- 高齢者の心血管疾患患者は,正確な生物学的年齢とリスク評価を必要とします.
- 脆弱性と生理学的備蓄の減少を示唆する脆弱性は,新興の臨床概念である.
- この研究では,老年性心筋梗塞患者の短期的なアウトカムに対する脆弱性の予測価値を調査しています.
研究 の 目的:
- 脆弱性が,非STセグメント上昇心筋梗塞の高齢患者の短期的な悪影響を予測するかどうかを判断する.
- 脆弱性の死亡率およびその他の主要な有害事象との独立した関連性を評価する.
- リスク予測のための脆弱性と併発性の組み合わせの有用性を探求する.
主な方法:
- 3つのセンターで非STセグメント上昇心筋梗塞を患った75歳以上の307人の患者を対象とした前向きなコホート研究.
- カナディアン・スタディ・オブ・ヘルス・アンド・エイジング (Canadian Study of Health and Aging) の臨床脆弱性スケールを用いて脆弱性を評価した.
- 冠動脈疾患特異指数を用いたリスク定量化;多重ロジスティック回帰による統計分析.
主要な成果:
- 患者のほぼ半分 (48.5%) が弱体として特定されました.
- 脆弱性は,プライマリコンポジットアウトカム (死亡,再発心,再血管化,入院,出血,脳卒中,1か月以内の透析) の2.2倍のリスク増加と独立して関連していました.
- 脆弱性は,病院での死亡率 (OR 4.6) と1ヶ月の死亡率 (OR 4.7) を有意に予測した.
結論:
- 脆弱性は,高齢の心筋梗塞患者の死亡率と有害な結果の強力な独立した予測因子です.
- それは長期の入院と,複合的な有害事象の結果と関連しています.
- 脆弱性および併発性の評価を組み合わせることで,複雑な心血管疾患の患者のための包括的なリスク予測戦略を提供します.
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