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関連する概念動画

Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the goblet,...
Stem Cell Niche01:26

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Adult Stem Cells01:33

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...
Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal01:22

Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal

Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.

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関連する実験動画

Updated: May 27, 2026

3D Culturing of Organoids from the Intestinal Villi Epithelium Undergoing Dedifferentiation
06:40

3D Culturing of Organoids from the Intestinal Villi Epithelium Undergoing Dedifferentiation

Published on: April 1, 2021

異なるニッチにおける腸の幹細胞集団間の相互変換

Norifumi Takeda1, Rajan Jain, Matthew R LeBoeuf

  • 1Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

Science (New York, N.Y.)
|November 15, 2011
PubMed
まとめ
この要約は機械生成です。

研究者らは,Hopxを+4腸幹細胞のマーカーとして特定した. これらの+4細胞は,暗号基柱状 (CBC) 細胞を生成し,CBCは+4細胞を生成し,幹細胞のタイプ間の双方向的な関係を明らかにすることができます.

さらに関連する動画

Establishment of Human Epithelial Enteroids and Colonoids from Whole Tissue and Biopsy
06:33

Establishment of Human Epithelial Enteroids and Colonoids from Whole Tissue and Biopsy

Published on: March 6, 2015

The Organoid Reconstitution Assay (ORA) for the Functional Analysis of Intestinal Stem and Niche Cells
09:38

The Organoid Reconstitution Assay (ORA) for the Functional Analysis of Intestinal Stem and Niche Cells

Published on: November 20, 2017

関連する実験動画

Last Updated: May 27, 2026

3D Culturing of Organoids from the Intestinal Villi Epithelium Undergoing Dedifferentiation
06:40

3D Culturing of Organoids from the Intestinal Villi Epithelium Undergoing Dedifferentiation

Published on: April 1, 2021

Establishment of Human Epithelial Enteroids and Colonoids from Whole Tissue and Biopsy
06:33

Establishment of Human Epithelial Enteroids and Colonoids from Whole Tissue and Biopsy

Published on: March 6, 2015

The Organoid Reconstitution Assay (ORA) for the Functional Analysis of Intestinal Stem and Niche Cells
09:38

The Organoid Reconstitution Assay (ORA) for the Functional Analysis of Intestinal Stem and Niche Cells

Published on: November 20, 2017

科学分野:

  • 胃腸内科 胃腸内科
  • 幹細胞生物学 幹細胞生物学
  • 発達生物学 発達生物学とは

背景:

  • 腸内皮質幹細胞は,組織ホメオスタシスにとって極めて重要です.
  • 2つの異なる幹細胞集団である+4細胞とクリプトベース柱状 (CBC) 細胞は,異なるニッチに存在する.
  • +4とCBC細胞の関係については,まだ十分に理解されていない.

研究 の 目的:

  • +4とCBCの腸内幹細胞の関係を解明する.
  • 異なる腸の幹細胞集団の特定のマーカーを特定するために.

主な方法:

  • +4 細胞の特定のマーカーとして Hopx を利用しました.
  • 腸内密室における系統追跡と細胞運命を決定する研究を行いました.

主要な成果:

  • Hopxは静止状態の+4腸幹細胞集団の特定のマーカーである.
  • +4 ホプクスを発現する細胞は,CBC細胞と他のすべての腸内表 epithelial 系統に微分化することができます.
  • Crypt base columnar (CBC) 細胞は,+4ホプックス陽性細胞にも微分化することができる.

結論:

  • 活発な (CBC) と静止 (+4) 腸の幹細胞の間に双方向的な系統関係が存在する.
  • この双方向的な関係は,腸内皮質の動的幹細胞の階層を強調しています.