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Updated: May 27, 2026

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
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Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

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ncRNAとPc2のメチル化に依存する,核構造間の遺伝子移動は,遺伝子活性化プログラムを媒介する

Liuqing Yang1, Chunru Lin, Wen Liu

  • 1Howard Hughes Medical Institute, University of California, San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093-0648, USA.

Cell
|November 15, 2011
PubMed
まとめ

ポリコンブ2タンパク質 (Pc2) のメチル化は,ノンコーディングRNA (ncRNA) を通して,核構造間の成長遺伝子移動を制御する. これは,核アーキテクチャと遺伝子発現の調節を結びつける.

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Chromatin Position Affects Gene Expression

Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
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