CD14は,LPS誘発のToll型受容体4のエンドサイトーシスを制御する
Ivan Zanoni1, Renato Ostuni, Lorri R Marek
1Harvard Medical School and Division of Gastroenterology, Children's Hospital Boston, Boston, MA 02115, USA.
Cell
|November 15, 2011
まとめ
CD14は,微生物が検出された後に,トール型受容体4 (TLR4) エンドサイトーシスを制御する. この経路は,SykとPLCγ2によって調節され,先天的免疫と dendritic 細胞の信号伝達に不可欠です.
科学分野:
- 免疫学 免疫学とは
- 細胞生物学 細胞生物学
- 分子生物学は分子生物学である.
背景:
- トール型受容体 (TLRs) 輸送は,先天性免疫調節の鍵である.
- 新しく合成されたTLR輸送のレギュレータは知られているが,後微生物検出のレギュレータは知られていない.
研究 の 目的:
- 微生物の検出後のトール型受容体4 (TLR4) 輸送のレギュレータを特定する.
- 微生物誘発のTLR4内分細胞とシグナル伝達におけるCD14の役割を明らかにする.
主な方法:
- dendritic 細胞における TLR4 エンドサイトーシスにおける CD14 の役割を調査した.
- TLR4のトラフィックとシグナル伝達におけるチロシンキナーゼSykとPLCγ2の関与を分析した.
主要な成果:
- CD14は,微生物によって誘発されたTLR4内分細胞化に不可欠です.
- CD14依存性エンドサイトーシス経路は, dendritic 細胞の炎症媒介体によって上調されます.
- SykとPLCγ2は,TLR4内分泌とシグナル伝達の重要なレギュレータとして特定されています.
結論:
- アップストリームのパターン認識受容体 (PRR) であるCD14は,微生物が検出されると,ダウンストリームのPRRであるTLR4の取引とシグナリングを制御する.
- この先天的な免疫密輸カスケードは,病原体検出における膜輸送と信号伝導の協調された動作を強調しています.
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