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Updated: May 27, 2026

Avidity-based Extracellular Interaction Screening (AVEXIS) for the Scalable Detection of Low-affinity Extracellular Receptor-Ligand Interactions
12:30

Avidity-based Extracellular Interaction Screening (AVEXIS) for the Scalable Detection of Low-affinity Extracellular Receptor-Ligand Interactions

Published on: March 5, 2012

双価リガンド-双価受容体モデルシステムにおけるリンカー長さに依存するアビディティの関係

Eric T Mack1, Phillip W Snyder, Raquel Perez-Castillejos

  • 1Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.

Journal of the American Chemical Society
|November 18, 2011
PubMed
まとめ

この研究は,炭酸アンヒドラゼ二重体と二価リガンドを使用して抗体と抗原の結合をモデル化しています. 双価結合は単価結合よりも著しく高い親和性を示したが,理論的な予測よりも弱かった.

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