関連する実験動画

計算により設計されたタンパク質ホモジマーにおける金属媒介の親和性および方向性特異性

Bryan S Der1, Mischa Machius, Michael J Miley

  • 1Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599-7260, USA.

Journal of the American Chemical Society
|November 19, 2011
PubMed
まとめ

研究者は,シンク媒介のホモジマーを作成するために,計算方法を使用してタンパク質モノマーを設計しました. この金属結合タンパク質の設計であるMID1は,亜鉛に対する高い親和性を示し,さまざまな用途で堅固なタンパク質-タンパク質相互作用を可能にします.

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